This List of Celebs Who May Have Cheated On Their Famous Partners With Other Stars Will Break Your Heart

Pitt hooked up with this A-list actress on the set of their film Mr. & Mrs. Smith. Any guesses, friends?

Jolie and Pitt began dating shortly after shooting their espionage thriller in 2005, and Jolie recently admitted in an interview that the pair did, in fact, fall in love on set. Whether they actually hooked up behind Aniston’s back is an entirely different story, and the pair remains mum on the subject.

Stewart made a public apology for cheating on her boyfriend and Twilight co-star.

Bella and Edward were destined for one another, but Pattinson couldn’t get over Stewart’s affair with her director.

The married Snow White and the Huntsman director was spotted canoodling with Stewart in 2012. Though he, too, issued a public apology, his marriage never recovered, and his wife filed for divorce later that year.

Jack and Rose weren’t the only ones who fell in love on the Titanic set — unfortunately, Cameron was already involved with this leading lady when he fell for someone new.

Hamilton and Cameron were living together when Cameron fell for this actress.

You may remember Amis as Rose’s granddaughter in the iconic film, but Hamilton probably remembers her as the “other woman” in the relationship between her and Cameron. Cameron allegedly couldn’t pick between the two actresses — he was wed to Hamilton for eight months before leaving her for Amis, whom he now has three children with.

America’s sweetheart has a love life right out of a romantic comedy. Or is it a drama?

Quaid and Ryan were married for nine years before the actress allegedly left him for her Proof of Life co-star in 2001.

The Les Miserables actor allegedly had a steamy affair with the married Ryan which resulted in the end of her marriage to Quaid.

The actor wasn’t faithful to his reality star wife and the result was one highly publicized affair.

The Real Housewives of Beverly Hills star was shocked to learn that her husband had cheated on her with his Lifetime movie co-star.

Rimes and Cibrian fell in love on the set of romantic Lifetime flick Northern Lights in 2008, while both were married to other people. The couple is now married and never misses a moment to trash talk Glanville — and, fittingly, the feeling is mutual.

The shock rocker and the burlesque dancer appeared to be the perfect match. Until, well, they weren’t.

Von Teese hinted in an interview that her rocky year-long marriage to the singer was made worse by his “inappropriate” relationship with a young actress.

Wood and Manson began dating in 2007, shortly after his marriage to Von Teese ended, making many wonder whether the 19-year-old was a factor in their breakup.

The Fargo actor wasted no time moving on from this actress with his Pushing Tin co-star.

As Dern puts it, she went away to work on a film and returned to find that her boyfriend had married someone else. She never heard from him again.

Jolie became Thornton’s fifth wife in 2000 and divorced three years later.

If you believe all those rumors, then the Biebs hasn’t exactly been the most faithful boyfriend to this singer/actress.

The “Heart Wants What It Wants” singer has had a rocky relationship with pop’s bad boy, but things came to a head when she heard rumors that he had hooked up with her pal.

Rumor has it that the model sent nude photos to her friend Gomez’s boyfriend while the pair were still together, prompting an immediate friendship ceasefire.

Danes and her co-star allegedly cheated on their own respective partners with one another before Danes romanced someone else behind his back.

Crudup was expecting a child with Weeds actress Mary Louise Parker when he hooked up with Danes. Unfortunately, the couple’s rocky beginning may have been a bad omen, because she left him for yet another co-star.

Danes allegedly hooked up with Dancy behind Crudup’s back after three years together. The pair is now married with a child.

Murray had to work with his ex-wife for years on their CW show, despite rumors of infidelity on his part.

Brooke and Lucas didn’t work out on One Tree Hill, and neither did Bush and Murray, who wed in 2004. Why? According to rumors, it might have had to do with a certain blonde heiress…

Murray and Hilton co-starred in House of Wax together and rumors swirled that they had an affair while on set. Whether or not that’s true, something made Bush angry enough to leave the marriage after a mere five months.

Jonas should have known better than to do wrong by this songstress.

Though it’s unclear as to whether Swift’s song “Better Than Revenge” is telling the truth about Jonas’ infidelity, Swift was none to happy that Jonas jumped into a relationship with this starlet after their breakup.

According to the rumors — fueled by Swift herself — Jonas hooked up with Belle on set of the Jonas Brothers music video “Lovebug,” which starred the actress, when he was still very much with Swift.

West’s ex-girlfriend has been vocal about the rapper’s infidelity.

Rose claimed that the reason for her split with the “Black Skinhead” rapper has a whole lot to do with this reality star.

Rose told Star Magazine that she found incriminating evidence that Kardashian and West were hooking up behind her back. Today Kardashian goes by Kardashian-West and is raising a baby with the rapper.