TV & Movies

The Grey’s Anatomy Cast Has Come A Long Way Since Their Intern Scrubs

From 2005 to today, here’s how much has changed.

Ellen Pompeo is one of three original cast members on 'Grey's Anatomy.' Photo via Getty Images
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Grey’s Anatomy is the longest-running primetime medical drama, and only three Day 1 cast members from 2005 are still series regulars. Here’s a look back at Ellen Pompeo, Chandra Wilson, James Pickens Jr., and the rest of the cast’s journeys on and off the show.

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It’s hard to imagine Grey’s without Pompeo — but she was hesitant to sign on at first. “I was like, ‘I’m not going to be stuck on a medical show for five years,’” she told her agent at the time, as she recounted to THR. “‘Are you out of your f*ckin’ mind? I’m an actress.’”