The 7 Best Hypoallergenic Sheets

Soft sheets that won’t kick up your allergies.

by Lisa Fogarty
Originally Published: 
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You can have the most gorgeous, soft, and silky bed sheets known to man, but if you're sneezing and coughing all night because of allergies, those beautiful sheets are not going to help give you a good night's sleep. Here's what will: the best hypoallergenic sheets, which are made from natural materials like cotton, bamboo, and eucalyptus, or a synthetic material with a tight weave that resists allergens.

What To Consider When Choosing Hypoallergenic Sheets

Paying attention to fabrics is crucial when it comes to shopping for hypoallergenic sheets. Some cotton sheets, and especially organic cotton, are free of pesticides and chemicals, which reduces the chance that they will kick up allergies. However, some cotton cons are that they wrinkle and can shrink in hot dryers, so extra care is needed to keep them in good shape. Choose cotton sheets that are GOTS-certified or meet OEKO-TEX standards to ensure they’ve been tested for chemicals. Bamboo is another natural fabric that is hypoallergenic, safe for sensitive skin, and breathable, though it is prone to wrinkles and more expensive than cotton. Newer on the scene, eucalyptus sheets are eco-friendly, hypoallergenic, antifungal, and antibacterial, as well as cooling and less prone to wrinkles than cotton or bamboo, but are also more expensive than cotton.

Synthetic microfiber sheets, which are usually the most affordable of all of these options, can also be hypoallergenic, but the trade-off is that they aren’t as breathable as natural fabrics. No matter which fabric you choose, a tight weave like sateen or percale is preferable if you have allergies because it creates a barrier against dust mites.

Shop The Best Hypoallergenic Sheets

In a hurry? These are the best hypoallergenic sheets on Amazon:

1. These 100% Cotton Sheets With A Sateen Weave: California Design Den Cotton Sheets Set

2. An Organic Cotton Sheet Set In A Crisp Percale Weave: Sleep Mantra Organic Cotton Sheets

3. This 100% Bamboo Sheet Set: Bedsure Bamboo Sheets

4. These Soft Sheets Made With Bamboo And Microfiber: Cosy House Collection Luxury Bamboo Sheets

5. A Sustainable Set Of Eucalyptus Sheets: Sheets & Giggles 100% Eucalyptus Lyocell Sheet Set

6. These Microfiber Sheets With A Cult Following: Mellanni Bed Sheet Set

7. These Extra Deep Pocket Microfiber Sheets: CGK Unlimited Extra Deep Pocket Sheets

Whether you need super affordable bed sheets or bed sheets to keep you cool at night, you'll find them here. What won't you find? Sheets that attract allergens and hold on to them for dear life. Your nights are about to become a lot more restful.


These 100% Cotton Sheets With A Sateen Weave

Designed with natural 100% cotton and a tight, lustrous sateen weave, this popular sheet set is hypoallergenic, cool, breathable, and passes OEKO-TEX standards — which means it has been independently tested to ensure it meets environmental standards. The four-piece set has earned more than 80,000 reviews on Amazon and is described as medium in thickness. It includes a flat sheet, an elasticized fitted sheet that can accommodate mattresses with up to 16-inch deep pockets, and two standard pillowcases. It comes in seven mattress sizes and 36 colors and prints that include leopard and plaid.

A helpful review: “After I washed these sheets, they are very nice, thick and comfortable. I will definitely order them again when I need to. My husband has allergies to everything. The 100% cotton aspect of these sheets has really helped his allergies tremendously!”

Material: 100% cotton | Sizes: Twin, twin XL, full, queen, king, California king, split king | Colors: 46


An Organic Cotton Sheet Set In A Crisp Percale Weave

If you love 100% cotton sheets but prefer a cooling, crisp set to one that is more lustrous, these percale cotton sheets are the hypoallergenic pick for you. These GOTS-certified sheets (which means they meet global organic textile standards and are grown without pesticides or chemicals) are made from 100% organic cotton, and the set includes a flat sheet, an elasticized fitted sheet for mattresses up to 14 inches deep, and two standard pillowcases. This set has more than 7,000 reviews and comes in nine colors.

A helpful review: “Incredible sheets. Exactly as advertised. Crisp, cool, & 100% cotton. Thread count is perfect, not to gritty, (low), and not too slick, (very high). They are a little stiff at first, but get softer with every wash.”

Material: 100% organic cotton | Sizes: Twin, twin XL, full, queen, king, California king | Colors: 9


This 100% Bamboo Sheet Set

It’s unusual to find a sheet set made with 100% bamboo, but these hit the mark. They are designed from 100% bamboo viscose fiber and are hypoallergenic, naturally moisture-wicking, and ideal for sensitive skin. The set includes a fitted sheet with an elastic band that fits mattresses with up to 16-inch deep pockets, a flat sheet, and two standard pillowcases. These have a high 4.5-star rating and more than 39,000 reviews, and they come in 13 colors.

A helpful review: “Love them, probably one of the most comfortable sets I’ve had. They are very soft and gentle on your skin; ultra breathable with a very cooling effect. Sliding into them is so smooth and relaxing, it instantly helps to relieve the day. They can wrinkle a little out of the dryer, but hold up nicely well during the week.”

Material: 100% bamboo | Sizes: Twin, twin XL, full, queen, king, California king | Colors: 13


These Soft Sheets Made With Bamboo And Microfiber

It's one thing (a pretty great thing) to own a set of luxury bamboo sheets that will never aggravate your allergies and are an enemy to dust mites everywhere. Add a cooling component, and you've got yourself the best luxury hypoallergenic bamboo sheets imaginable. This four-piece set is made with a high 40% bamboo rayon and 60% microfiber, which helps make them resistant to wrinkles and softens them a bit.

The regenerated cellulose fiber from rayon helps regulate your body temperature, so you'll be kept cool throughout the night. The durable, quality sheets come in 13 colors, and the set includes a deep-pocket fitted sheet that fits mattresses up to 16 inches deep, a flat sheet, and two standard pillowcases. Avoid pilling by making sure you wash them in cold water and dry them in low heat.

If you’re searching for even more colors, check out this bamboo blend sheet set that comes in over 40 shades.

A helpful review: “I absolutely adore these sheets! This is my third pair and have replaced all my other sheets with these. They are soft, cooling, and wrinkle free. I think my favorite feature is the built in corner bands to keep them from popping off. They are very breathable and keep myself warm and my husband cool.”

Material: 40% bamboo, 60% microfiber | Sizes: Twin, full, queen, king, California king | Colors: 13


A Sustainable Set Of Eucalyptus Sheets

This unique set of eucalyptus Lyocell sheets are USDA-certified biobased and are derived from trees that are renewably grown without pesticides and chemicals. These naturally hypoallergenic sheets are designed with a tight sateen weave, and the set includes a fitted sheet that can fit mattresses up to 20 inches deep, a flat sheet, and two standard pillowcases. These highly rated sheets are described as soft, temperature-regulating, and resistant to static. They come in 11 colors.

A helpful review: “I have spent a lot of money on different sheets but this has been the best. I used to get super itchy at night [...] but once I moved to this I don’t think I will buy any other sheets. It’s super soft, and hypoallergenic and good for people with eczema. Worth the money!”

Material: 100% eucalyptus Lyocell | Sizes: Twin, twin XL, full, queen, king, California king | Colors: 11


These Microfiber Sheets With A Cult Following

If a set of hypoallergenic bed sheets could win the "most popular" vote, it would go to this four-piece brushed microfiber set by Mellanni. With more than 325,000 mostly amazing reviews and a high rating, these sheets score major points for being as soft as silk, more durable than cotton, and for keeping allergy sufferers sneeze-free throughout the night. They're resistant to dust mites, hold up after countless spins in the washing machine and dryer, and won't wrinkle, fade, or stain.

Also consider that these are an amazing set of sheets that look far more polished than they have any right to, given their affordable price. Not only can you score them in 42 colors and designs (like elegant quatrefoil), but they're also available in a wide range of sizes, including split king and twin XL.

A helpful review: “Definitely one of the bed sheets I've ever had! The material is very soft and feels great against your skin. Also, I've noticed that lately I no longer have a stuffy nose when I wake up since they are hypoallergenic.”

Material: 100% microfiber | Sizes: Twin, twin XL, full, short queen, queen, king, California king, split king (extra deep pocket sheets also available) | Colors: 42


These Extra Deep Pocket Microfiber Sheets

There's affordable — and then there's the kind of affordable that makes you want to buy these hypoallergenic bed sheets in multiple colors — especially if you have an extra-deep mattress. This six-piece sheet set includes a deep-pocket fitted sheet with an all-around elastic that can fit mattresses between 18 and 24 inches deep and is made from soft, anti-allergen microfiber, which feels smooth and soft and washes like a dream (no wrinkles, no ironing — no complaints there). The set also includes a flat sheet and four standard pillowcases. These sheets have more than 65,000 reviews and come in 19 colors.

A helpful review: “I really am enjoying these sheets. [...] I've been having lots of issues with allergies lately and so far I am happy to say these sheets have been soft, comfortable and no issues with any allergies. Very happy with my purchase.”

Material: 100% microfiber | Sizes: Twin, twin XL, full, queen, king, California king, split king | Colors: 19

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