21 Alex Karev 'Grey's Anatomy' Moments That Show How Much The OG Cast Member Will Be Missed

Mike Rosenthal/ABC

For 16 years, Justin Chambers has been a constant in the lives of many TV watchers, providing countless hilarious, moving, memorable moments as Alex Karev on Grey's Anatomy. He has been a rock for the show, one of only four original cast members left a decade and a half into the series' run, and one of only two of the original crop of interns left, along with Meredith — which just makes it that much harder to say goodbye. It turns out that the last time viewers saw Alex was the last time viewers will ever see Alex, even if they didn't know it, as Justin Chambers announced during the show's winter hiatus that he (and therefore Alex) was leaving Grey's, and that his final episode had already aired on Nov. 14.

Of course, Dr. Karev is far from the first main cast member to depart the long-running medical soap; over the years, fans have gotten used to saying hard farewells to beloved characters like Derek, Cristina, George, Izzie, Callie, Arizona, April, and many more. But most of those characters either got a tragic, memorable death or an emotional, satisfying sendoff… which makes Alex's sudden vanishing even more bizarre. The last time viewers saw the character, he was speaking in defense of Meredith at her trial; in the next episode, Season 16's midseason finale, it was mentioned that he had gone to visit his mother, but no indication was given that he would never return.

While viewers continue to grapple with this sudden loss, take a moment to look back at some of Alex Karev's best moments over the last 16 years, as he transitioned from "Evil Spawn" into Meredith's reliable "person" — a truly remarkable character arc.

1. When He & Cristina Competed

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Season 1, Episode 2: "The First Cut Is The Deepest"

Alex truly earned his "Evil Spawn" reputation in Season 1, talking down to nurses and posting pictures of Izzie's lingerie shoot around the locker room. But he still had his endearing, comedic moments, such as when he and Cristina competed to see who could deliver the most test results while dodging the most hugs from grateful, tearful patients.

2. When He Gave George Syphilis

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Season 1, Episode 9: "Who's Zoomin' Who?"

In the Season 1 finale, George was distraught to learn that he'd contracted syphilis from his nurse girlfriend, Olivia. However, he was even more distraught to learn that Olivia had contracted the syphilis from Alex of all people — so Alex indirectly gave George the STD.

3. When He Comforted Izzie After Denny's Death

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Season 2, Episode 27: "Losing My Religion"

14 years later, and this is probably still THE iconic Alex Karev moment. Upon entering Denny's hospital room and seeing Izzie sobbing in her prom dress, in bed next to her recently deceased fiancé, Alex tenderly scooped her up and held her while she (and the audience) cried.

4. When He Kissed Addison

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Season 3, Episode 12: "Six Days, Part 2"

Over the course of 16 seasons, Alex would go on to have many relationships, two marriages, and at least one true love. Compared to his long-term couplings with Izzie and Jo, Addison was but a blip on Alex's radar; but in terms of pure sex appeal, their brief fling together was one of the show's most sizzling.

5. When He Tried To Take Care Of Ava/Rebecca

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Season 4, Episode 17: "Freedom, Part 2"

Although Alex had earlier told ferry boat victim Ava/Rebecca to go back to her husband because he, unlike Alex, was a "decent guy," Alex proved how decent he actually is after the mentally unstable former patient attempted to take her own life. He insisted he could take care of her because he'd done it before, taking care of his own mentally unstable mother — a moment that revealed a lot about the character's past and shed light on his increasingly complex personality.

6. When He Married Izzie

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Season 5, Episode 22: "What A Difference A Day Makes"

Although their happily ever after didn't turn out to be happily forever after, it was still beautiful in the moment, as the longtime on-again-off-again couple finally said their vows and tied the knot. The moment was made even more meaningful by the fact that Izzie was potentially dying of cancer, and the ceremony had been gifted to them wholesale by Meredith and Derek, who were originally meant to be the ones getting married.

7. When He Screamed At A Bear

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Season 6, Episode 4: "Tainted Obligation"

After getting married, Alex and Izzie realized they needed to move out of Meredith's house into a place of their own, so they set up temporary residence in Derek's trailer instead. That peaceful honeymoon in the woods came to an abrupt end when a grizzly bear surprised Alex on the front porch as the doctor was headed to work in the morning.

8. When He Performed The Kangaroo Hold

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Season 6, Episode 8: "Invest In Love"

Realizing that skin-to-skin contact will help improve an ailing baby's condition, Bailey ordered Alex to take off his shirt and hold the tiny patient to his chest, the sight of which was an odd combination of sweet and sexy — which is a good way to sum up Alex Karev, when you think about it.

9. When He Stood Up For Himself

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Season 6, Episode 12: "I Like You So Much Better When You're Naked"

Unfortunately, Alex and Izzie's fairytale marriage didn't last for long; their relationship was thrown into turmoil when Izzie was fired from the hospital and left Alex without saying goodbye, assuming he had something to do with it. When Izzie returned to tell Alex she was finally cancer free, Alex told his wife he was happy for her, and thanked her for helping him realize he was a good man… but that he realized he was a good enough man that he deserved someone who would stay with him.

10. When He Sang Camp Rock

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Season 7, Episode 6: "These Arms Of Mine"

Alex continued to prove he's surprisingly good with patients — especially children — when he comforted a nervous young patient, who found relief in music but couldn't take her iPod into the machine, by singing her favorite song while she received her scans.

11. When He & Meredith Were A Couple (Sort Of)

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Season 8, Episode 13: "If/Then"

Legions of Merlex shippers got to see their dream briefly come true — well, sort of — when Grey's aired this alternate reality episode that depicted a universe where Ellis Grey never developed Alzheimer's, Meredith wasn't dark and twist, and she was happily engaged to Alex Karev, of all people. Well, happily until she found out her fiancé was cheating on her with April Kepner. Apparently Alex is "Evil Spawn" at some point in all timelines.

12. When He Stayed With His Dying Father

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Season 10, Episode 13: "Take It Back"

Alex's dad's second family couldn't find it in themselves to forgive him and left while he was on death's doorstep after refusing to see him. Having absolved Jimmy in the previous episode for leaving his family when Alex was just a kid, Dr. Karev sat by his absentee father's bedside and kept him company as he breathed his last breaths.

13. When He Comforted Meredith After Her Attack

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Season 12, Episode 9: "The Sound Of Silence"

After Meredith was brutally attacked by a patient and wound up with severe injuries, Alex comforted his "person" by climbing into bed with her and holding her while she cried. Then he made her laugh by pointing out how much snot she'd gotten all over herself.

14. When He Asked For Waffle Sundays

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Season 13, Episode 6: "Roar"

In this touching moment, Alex told Meredith he wanted to enjoy "Waffle Sundays" with her and her kids before he was locked up in prison for assaulting Dr. DeLuca. He also told his "person" to be nicer to her sisters since, as he warned her, "I'm not gonna always be around." Little did he (or we) know how prescient those words would turn out to be.

15. When He Apologized To DeLuca

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Season 13, Episode 12: "None Of Your Business"

They say it's better late than never and, while Alex could have apologized to Andrew sooner for beating him up, at least he finally did the decent thing and owned up to his mistake — something the "Evil Spawn" of Season 1 never would have been capable of doing.

16. When He Took Out A Library Card

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Season 14, Episode 22: "Fight For Your Mind"

After taking a road trip to reconnect with his estranged mother, Alex was both pleased to see her doing so well, and sad to learn that having her son back in her life would be too much disruption to the routine that had allowed her to reach a mentally stable place. But he found a way to maintain her routine so they could have one last chat, asking to open up a library card while they said goodbye.

17. When He Married Jo

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Season 14, Episode 24: "All Of Me"

Second time's the charm? Although Alex's first marriage didn't work out, it's hard to believe his wedding to Jo won't stick. Their romantic and impromptu exchange of vows on a ferry boat was romantic and perfect — if not legally binding.

18. When He Became Chief Of Surgery

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Season 15, Episode 2: "Broken Together"

When Bailey decided to take a step back from her position as Chief so she could re-focus more on medicine and less on administrative duties, she asked Alex to step in for her on an interim basis. And in the blink of an eye, Meredith's "person" also became her boss.

19. When He Put His Job On The Line For Meredith

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Season 15, Episode 25: "Jump Into The Fog"

When Meredith was on the verge of being fired by Bailey and Catherine for insurance fraud, Alex and Richard jumped into the fray to back her up and put their own jobs on the line to defend their colleague. Unfortunately, that selfless act ended up backfiring as all three doctors were fired by an irate Bailey.

20. When He Re-Proposed To Jo

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Season 16, Episode 1: "Nothing Left To Cling To"

When Jo checked herself in to a clinic to deal with the emotional trauma of learning the truth about her conception, she gave Alex an out: as they weren't legally married, he could walk away at any time. But when Jo checked out a few weeks later, Alex was there waiting for her… and got down on one knee to re-propose to Jo and promise that he wasn't going anywhere.

21. When He Defended Meredith

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Season 16, Episode 8: "My Shot"

Meredith's "person" really rose to the occasion when Dr. Grey was put on trial for insurance fraud. First, he brought out a large group of Meredith's former patients who had arrived to show their support; then he read out loud a letter written by Cristina in Meredith's defense, and had many more letters from other beloved departed characters as well, like Callie and Arizona and April and Addison. A truly tear-jerking moment.

You will truly be missed, Evil Spawn. Grey's Anatomy will simply not be the same without you.